Nipro: Opinion on the creation of an American holding company and the reorganization of subsidiaries in the Americas

January 11, 2022

NIPRO COMPANY

Opinion on the creation of the American holding company and

Reorganization of Subsidiaries in the Americas

As stated in the “Notice on the establishment of the preparatory office for the American holding company and the reorganization of the American subsidiaries” published on April 1, 2020, Nipro had established a preparatory office for the establishment of its American holding company in Miami, Florida, United States, and was working to create a company that controls our business units located in the Americas to promote the expansion of our global business and enhance regional strategy. We hereby announce that we have created a US holding company and reorganized our subsidiaries located in the Americas.

1. Purpose of the constitution of the Holding and the reorganization of the subsidiaries

Nipro already has a holding company established in Europe and China. In the United States, we have recently established Nipro Holding Americas, Inc. as an American holding company, with the main aim of promoting business development adapted to local circumstances, rapid decision-making and strengthening of the business management system, and we reorganized our subsidiaries located in the Americas.

In addition to the above, the new Holding company will integrate the fund management of US subsidiaries under its control to improve management efficiency while providing shared services for operations such as accounting and human resource management, thus helping to optimize the operations of the entire Group.

2. Subsidiary Reorganization Scheme

1. Overview of the reorganization

On August 24, 2021, Nipro Holding Americas (NHA) was established as a wholly owned subsidiary of the Company.

On January 1, 2022, the Company transferred the shares of Nipro Medical Corporation (NMC) and the subsidiaries grouped under NMC to NHA.

(2) Presentation of the Holding

1. Subsidiaries subject to reorganization [Medical-related business]
2. • Nipro Medical Society
   • 1. Date created: March 07, 1996
     2. Majority shareholder and its ownership rate: Before transfer: Nipro 100% After transfer: Nipro Holdings Americas 100%
     3. Business overview: Sales of medical devices
     4. Location: Florida, United States
   • Avantec Vascular Corporation
   • 1. Date created: December 20, 1999
     2. Majority shareholder and its holding rate: Before sale: NMC 100% After sale: NHA 100%
     3. Business overview: Development of medical devices
     4. Place: california, united states
   • Infraredx, Inc.
   • 1. Date created: November 16, 1999
     2. Majority shareholder and its holding rate: Before sale: NMC 100% After sale: NHA 100%
     3. Business overview: Manufacture and sale of medical devices
     4. Location: Massachusetts, United States
   • NOTew England Cell Therapeutics, Inc.
   • 1. Date created: November 15, 2019
     2. Majority shareholder and its holding rate: Before sale: NMC 100% After sale: NHA 100%
     3. Business overview: Research and development, manufacture and sale of regenerative medicine products
     4. Location: Connecticut, USA
   • Nipro Medical Ltda.
   • 1. Date created: August 17, 1995
     2. Majority shareholder and its holding rate: Before sale: NMC 100%

After transfer: NHA 100%

• 1. Business overview: Manufacturing of medical devices
  2. Location: Sao Paulo, Brazil
• Salbego Laboratorio Farmaceutico Ltda.
• 1. Date created: June 27, 1989
  2. Majority shareholder and its holding rate: Before sale: NMC 100% After sale: NHA 100%
  3. Business overview: Dialysate manufacturing
  4. Location: Rio Grande do Sul, Brazil

[Pharma packaging business]

• Nipro PharmaPackaging Americas Corp.
• 1. Date created: 07 July, 2011
  2. Majority shareholder and its holding rate: Before sale: NMC 100% After sale: NHA 100%
  3. Business overview: Manufacture and sale of medical glass products
  4. Location: New Jersey, United States

3 Impact on business results

The impact of disposals of shares, etc. related to the constitution of the Holding on the result of the current financial year is not significant.